There’s an entire area of research dedicated to discovering all the various ways in which people age, and the things that could be done to halt and eventually reverse those effects.
One particularly interesting area of study involves calorie restriction. Mice living on an extremely limited calorie diet have been shown to live significantly longer. Although it has not been proven to work in humans (and seems really uncomfortable) some have been willing to give such an extreme diet a shot.
We’re firm believers in the next best thing – taking a pill. The closest thing to that would be something like resveratrol, a compound found in red wine, which mimics the effects of a calorie restricted diet.
Sirtris, the company Dr. Sinclair co-founded, says it has made progress. Test-tube and animal studies suggest that its early-stage drugs may help treat various neurological killers as well as diabetes, says Dr. Westphal. The company plans soon to begin testing a drug in people with MELAS syndrome, a rare metabolic disorder that afflicts youngsters with potentially fatal brain and muscle deterioration.
At a recent meeting on aging research, a Sirtris scientist reported that SIRT1-activating compounds, including resveratrol, dramatically lowered blood levels of glucose and insulin in mice that get diabetes on high-fat diets, as well as helped to keep their weight down — just as CR does.
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